Effectiveness of Comprehensive Lifestyle Interventions on Disease Activity and Quality of Life in Patients with Systemic Lupus Erythematosus in Pakistan
Diet, Exercise, and Stress Management in Managing Systemic Lupus Erythematosus
DOI:
https://doi.org/10.69750/dmls.01.04.046Keywords:
Systemic lupus erythematosus, lifestyle intervention, disease activity, quality of life, randomized controlled trial, diet, exercise, stress management.Abstract
Background: Systemic lupus erythematosus (SLE), is a chronic autoimmune illness that significantly lowers quality of life in its victims. Although pharmaceutical therapies are the norm, more focus is being paid to lifestyle changes as a means of controlling disease activity.
Objectives: The impact of a comprehensive lifestyle intervention program on patients' quality of life and disease activity with systemic lupus erythematosus was assessed in this research.
Methodology: Total 100 individuals with systemic lupus erythematosus were enrolled in a randomized controlled experiment and split into two groups: the intervention group (n = 50) and the control group (n = 50). Over a six-month period, the intervention comprised stress management, consistent exercise, and dietary adjustments. Changes in the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) Scores were the primary endpoint; quality of life, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were the secondary objectives.
Results: The SLEDAI scores of the intervention group were significantly lower than those of the control group (mean change: -4.2 vs. -1.3, p<0.01). Improvements in the SF-36 survey's physical and mental components showed a substantial increase in quality of life. Furthermore, there were higher drops in blood serum CRP and ESR levels in the intervention group (CRP: -3.5 mg/L vs. -1.2 mg/L, p≤0.05; ESR: -10 mm/hr vs. -3 mm/hr, p≤0.05).
Conclusion: Diet, exercise, and stress management are examples of lifestyle therapies that have been shown to dramatically lower disease activity and enhance quality of life in SLE patients. The inclusion of lifestyle adjustments in standard SLE treatment procedures is supported by these findings.
Downloads
References
Held M, Sestan M, Jelusic M. Obesity as a comorbidity in children and adolescents with autoimmune rheumatic diseases. Rheumatol Int. 2023;43(2):209–19. doi:10.1007/s00296-022-05238-6
Alvarez MC, Albuquerque MLL, Neiva HP, Cid L, Rodrigues F, Teixeira DS, et al. Exploring the relationship between fibromyalgia-related fatigue, physical activity, and quality of life. Int J Environ Res Public Health. 2022;19(8):4870. doi:10.3390/ijerph19084870
Gong Y, Wei W, Zhang W, Han Q, Zhang C. Implementation effect of a hierarchical pharmaceutical service pattern in patients with systemic lupus erythematosus. J Int Med Res. 2023;51(2):3000605231154749. doi:10.1177/03000605231154749
Rutter SJ, Kiemle G. Exploring social and interpersonal experiences of South Asian women with systemic lupus erythematosus. Psychol Health. 2015;30(3):318–35. doi:10.1080/08870446.2014.972397
Pasdaran A, Hassani B, Tavakoli A, Kozuharova E, Hamedi A. Herbal medicines, natural small molecules and supplements in lupus conditions. Life (Basel). 2023;13(7):1589. doi:10.3390/life13071589
Mazlan SA, Ahmad Shroni SK. Quality of life and work productivity among women with skin disease: multicenter cross-sectional study. Malays J Nurs. 2024;15(4):12–22. doi:10.31674/mjn.2024.v15i04.003
González L, Toloza S, McGwin G, Alarcón G. Ethnicity in systemic lupus erythematosus: influence on susceptibility and outcomes. Lupus. 2013;22(12):1214–24. doi:10.1177/0961203313502571
Khushnood K, Qureshi S, Sultan N, Altaf S, Ali Awan MM, Mehmood R. Exergaming to improve balance confidence and quality of life in diabetes. J Riphah Coll Rehabil Sci. 2020;8(2):78–82. doi:10.5455/JRCRS.2020080208
Cherry L, Alcacer-Pitarch B, Hopkinson N, Teh LS, Vital EM, Edwards CJ, et al. Lower limb and foot problems in systemic lupus erythematosus: UK national survey. Lupus. 2017;26(4):410–6. doi:10.1177/0961203316670730
Kadam E, Javaid M, Sen P, Saha S, Ziade N, Day J, et al. Voice of people with autoimmune diseases: COVAD phase 3 methodology. Rheumatol Int. 2024;44(7):1233–44. doi:10.1007/s00296-024-05562-z
Barati M, Ghahremani A, Namdar Ahmadabad H. Intermittent fasting as a promising intervention for autoimmune diseases. Autoimmun Rev. 2023;22(10):103408. doi:10.1016/j.autrev.2023.103408
Téllez Arévalo AM, Quaye A, Rojas-Rodríguez LC, Poole BD, Baracaldo-Santamaría D, Tellez Freitas CM. Synthetic pharmacotherapy for systemic lupus erythematosus. Medicina (Kaunas). 2023;59(1):56. doi:10.3390/medicina59010056
Wu J, Zhang WH, Ma J, Bao C, Liu J, Di W. Prediction of fetal loss in pregnant SLE patients: retrospective cohort. BMJ Open. 2019;9(2):e023849. doi:10.1136/bmjopen-2018-023849
Ibrahim MRK, Waly NGFM, Moness H, Ahmed SS, Ibrahem R. Serum miRNA-21, miRNA-146a and cfDNA as biomarkers in SLE. Mol Biol Rep. 2023;50(12):10025–36. doi:10.1007/s11033-023-08845-z
Ramírez J, Azuaga-Piñango AB, Celis R, Cañete JD. Cardiovascular risk and obesity in psoriatic arthritis: update. Front Med (Lausanne). 2021;8:742713. doi:10.3389/fmed.2021.742713
Peng X, Zhang J, Wan L, Wang H, Zhang W. Seven-step rehab program after PCI for AMI: effect on cardiac function & QoL. Pak J Med Sci. 2022;38(1):123–7. doi:10.12669/pjms.38.1.4945
Aghamohammadi D, Ayromlou H, Dolatkhah N, Jahanjoo F, Shakouri SK. Probiotic Saccharomyces boulardii in multiple sclerosis: RCT protocol. Trials. 2019;20(1):379. doi:10.1186/s13063-019-3454-9
Poorani KM, Fatima M, Abbasiq M, Khimani V, Kumar Luhano M, Ali MH. Osteopenia among children with chronic diseases. Pak J Med Res. 2022;61(2):74–8.
Ozdemir F, Cansel N, Kizilay F, Guldogan E, Ucuz I, Sinanoglu B, et al. Physical activity and mental health during COVID-19 outbreak. Eur J Integr Med. 2020;40:101248. doi:10.1016/j.eujim.2020.101248
Downloads
PlumX Metrics
Published
Issue
Section
License
© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License , which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third-party material in this article are included in the article’s Creative Commons license unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you must obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ . The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/ ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
How to Cite
