The Impact of High BMI on Cholesterol Levels and Type-2 Diabetes Control. A Cross-Sectional Study
High BMI: Effects on Cholesterol and Type-2 Diabetes Control
DOI:
https://doi.org/10.69750/dmls.01.01.018Keywords:
Glycosylated hemoglobin, Hypercholesterolemia, Body mass index, Glycemic Index. Diabetes Type-2.Abstract
Background: Higher levels of BMI have closed relationship with hypercholesterolemia and glycated hemoglobin (HbA1c) in the population with type 2 diabetes.
Study Design: Present research was a Cross-Sectional Study.
Methodology: Current study was conducted at Lahore General Hospital, Jinnah hospital Lahore and Diabetes Endocrine Metabolic Centre (DEMC) from March 2023 to February 2024. A retrospective Cross-Sectional analysis of 800 patients was considered and correlation between BMI, HbA1c and hypercholesterolemia was noted. The Underweight, Normal, Overweight, Obesity Class 1, Obesity Class 2, and Obesity Class 3 were the six categories based on BMI. One could classify HbA1c as controlled or uncontrolled. One could take cholesterol as controlled or uncontrolled.
Results:For above 500 patients, 25 percent had normal weight, 30.1% were overweight, and 35 percent were obese. Class 1 had a 25.8% obesity rate, Class 2 had a 40% obesity rate, and Class 3 had a 42 % obesity rate. Both sexes showed similar levels of obesity, HbA1c, and cholesterol control. Whereas 32.26% of patients had a controlled HbA1c. Of them, 7.8% had normal weight, 11.8% were overweight, and 0.98% were underweight. In this class, 11.8% of the patients were obese. Class 1 obesity rates were 6.2%, Class 2 obesity rates were 4.3%, and Class 3 obesity rates were 1.2%. 1.9% of patients with uncontrolled HbA1c levels were underweight, 18.2% were of normal weight, 22.1% were overweight, and 26.3% were obese out of 67.74% of patients. Class 1 obesity rates were 18.7%, Class 2 obesity rates were 6.3%, and Class 3 obesity rates were 1.4%.
Conclusion:The findings of present study were showed that BMI has close relationship with HbA1c. And hypercholesterolemia. High levels of BMI had poor glycemic and Cholesterol control.
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References
Bener A, Zirie M, Al-Rikabi A. Genetics, obesity, and environmental risk factors associated with type 2 diabetes. Croat Med J. 2005;46(2):302-7.
Liu H, Liu J, Liu J, Xin S, Lyu Z, Fu X. Triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, a simple but effective indicator in predicting type 2 diabetes mellitus in older adults. Frontiers in Endocrinology. 2022;13:828581.
Khil J, Kim SM, Chang J, Choi S, Lee G, Son JS, et al. Changes in total cholesterol level and cardiovascular disease risk among type 2 diabetes patients. Scientific Reports. 2023;13(1):8342.
RIAZ M, QAZI AMQ, Syed SA, Chaudhary AK. HEPATOPROTECTIVE EFFECTS OF GLYCYRRHIZ GLABRA AND CICORIUM INTYBUS IN PARACETAMOL INDUCED TOXICITY IN RATTUS NORVEGICUS. DEVELOPMENTAL MEDICO-LIFE-SCIENCES. 2024;1(1).
Gutierrez MJ, Rosenberg NL, MacDougall DE, Hanselman JC, Margulies JR, Strange P, et al. Efficacy and safety of ETC-1002, a novel investigational low-density lipoprotein-cholesterol–lowering therapy for the treatment of patients with hypercholesterolemia and type 2 diabetes mellitus. Arteriosclerosis, thrombosis, and vascular biology. 2014;34(3):676-83.
Kim MK, Han K, Joung HN, Baek K-H, Song K-H, Kwon H-S. Cholesterol levels and development of cardiovascular disease in Koreans with type 2 diabetes mellitus and without pre-existing cardiovascular disease. Cardiovascular diabetology. 2019;18:1-11.
Hussain R, Umar M, Shuja M, Khowaja S, Jabeen S, Shah SSA. During Resistance Training the Effect of Ibuprofen on Muscle Hypertrophy Regarding Strength and Soreness. A Population Based Cross-Sectional Study. Pakistan Journal of Medical & Health Sciences. 2023;17(05):471-.
Wang JS, Lo SH, Yeh YP, Hwu CM, Huang CN, Hsieh CH, et al. Distinct associations of self‐monitoring of blood glucose with glycemic control and hypoglycemia between groups of recently diagnosed and long‐term follow‐up type 2 diabetes: the Taiwan diabetes registry. International Journal of Clinical Practice. 2021;75(9):e14410.
Rahmy AF, Afifi WM, Ghorab AA, Mostafa HA. Effect of moderate aerobic exercises on kidney function and lipid profile in chronic kidney disease patients. Journal of The Egyptian Society of Nephrology and Transplantation. 2016;16(3):97-105.
Jende JM, Groener JB, Rother C, Kender Z, Hahn A, Hilgenfeld T, et al. Association of serum cholesterol levels with peripheral nerve damage in patients with type 2 diabetes. JAMA network open. 2019;2(5):e194798-e.
RASHID M, SHAHBAZ MN, AKRAM A, ANWAR A, UMAR M, ALI MS, et al. Analysis of Patients Receiving Treatment for Inflammatory Breast Disease at Surgery Department of Tertiary Care Units. DEVELOPMENTAL MEDICO-LIFE-SCIENCES. 2024;1(1).
Adedeji TA. Risk Factors for Overweight and Obesity in College Students: Howard University; 2017.
Russo G, Pintaudi B, Giorda C, Lucisano G, Nicolucci A, Cristofaro MR, et al. Age-and gender-related differences in LDL-cholesterol management in outpatients with type 2 diabetes mellitus. International Journal of Endocrinology. 2015;2015.
Jaber AaF. THE ASSOCIATION BETWEEN PHYSICAL ACTIVITY, COGNITIVE FUNCTION, AND PERFORMANCE OF ACTIVITIES OF DAILY LIVING IN PATIENTS WITH EARLY ALZHEIMER'S DISEASE: University of Kansas; 2010.
Fu Q, Zhang Z, Hu W, Yang Y. The correlation of triglyceride/high-density lipoprotein cholesterol ratio with muscle mass in type 2 diabetes patients. BMC Endocrine Disorders. 2023;23(1):93.
Chen L, Pei J-H, Kuang J, Chen H-M, Chen Z, Li Z-W, et al. Effect of lifestyle intervention in patients with type 2 diabetes: a meta-analysis. Metabolism. 2015;64(2):338-47.
Praveen EP, Kulshreshtha B, Khurana ML, Sahoo J, Gupta N, Kumar G, et al. Low HDL-cholesterol among normal weight, normoglycemic offspring of individuals with type 2 diabetes mellitus. Hormones. 2011;10:57-66.
Lotta LA, Sharp SJ, Burgess S, Perry JR, Stewart ID, Willems SM, et al. Association between low-density lipoprotein cholesterol–lowering genetic variants and risk of type 2 diabetes: a meta-analysis. Jama. 2016;316(13):1383-91.
Li K, Cao B, Wang X, Chai T, Ke J, Zhao D. Sex differences in the non-linear association between BMI and LDL cholesterol in type 2 diabetes. Frontiers in Endocrinology. 2023;14:1180012.
Liu H, Yan S, Chen G, Li B, Zhao L, Wang Y, et al. Association of the ratio of triglycerides to high-density lipoprotein cholesterol levels with the risk of type 2 diabetes: a retrospective cohort study in Beijing. Journal of Diabetes Research. 2021;2021.
Youk TM, Kang MJ, Song SO, Park E-C. Effects of BMI and LDL-cholesterol change pattern on cardiovascular disease in normal adults and diabetics. BMJ Open Diabetes Research and Care. 2020;8(2):e001340.
Cheng C, Liu Y, Sun X, Yin Z, Li H, Zhang M, et al. Dose–response association between the triglycerides: High‐density lipoprotein cholesterol ratio and type 2 diabetes mellitus risk: The rural Chinese cohort study and meta‐analysis. Journal of diabetes. 2019;11(3):183-92.
Franz MJ, Boucher JL, Rutten-Ramos S, VanWormer JJ. Lifestyle weight-loss intervention outcomes in overweight and obese adults with type 2 diabetes: a systematic review and meta-analysis of randomized clinical trials. Journal of the Academy of Nutrition and Dietetics. 2015;115(9):1447-63.
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