Impact of Consistent and Inconsistent Creatine Kinase-MB and Troponin Levels on Hospital lethality in Acute Coronary Disorder

Creatine Kinase-MB and Troponin as Mortality Predictors

Authors

  • Syed Wajeeh Ur Rehman Shah International Medical University, Kyrgyzstan, Bishkek, Kyrgyzstan Author
  • Hira Shehzadi Hainan Medical University, Haikou, China Author
  • Neelam Shahzadi Karachi Institute of Medical Sciences(KIMS),Karachi, Pakistan Author
  • Zainab khalid University College of Medicine and Dentistry(UCMD), Lahore, Pakistan Author
  • Muhammad Naeem University College of Medicine and Dentistry(UCMD), Lahore, Pakistan Author
  • Raman Latif Qureshi Fatima Jinnah Medical University,Lahore, Pakistan Author
  • Mubeen Fatima Department of Forensic Sciences , Lahore University of Biological & Applied Sciences (UBAS), Lahore, Pakistan Author

DOI:

https://doi.org/10.69750/dmls.01.07.055

Keywords:

Myocardial Infarction, Prognosis., Creatine Kinase, MB Form, Troponin, Acute Coronary Syndrome, Biomarkers, Hospital Mortality, Logistic Models.

Abstract

Background: Serum CK-MB and cardiac troponin are important diagnostic predictors used to determine the prognosis of patients with acute coronary disorders (ACD). However, the effects of these biomarkers on hospital lethality remain underexplored.

Objective: This research aimed to determine the effects of consistent and inconsistent CK-MB and troponin levels on hospital mortality in ACD patients.

Methodology: This comparative study was conducted on patients with confirmed ACD admitted to a tertiary care hospital from January 2023 till June 2024. Patients were categorized into two groups based on the consistency of their CK-MB and troponin levels during hospitalization: consistently elevated or normal biomarkers versus those with variable levels. Hospital lethality was defined as mortality occurring during the hospital stay. SPSS version 26 was used for statistical analysis. The study utilized multivariate logistic regression to ascertain independent factors that are associated with hospital death. For continuous variables, t-tests or Mann-Whitney U tests were employed, and for categorical data, chi-square tests.

Results: There were 500 patients in the trial; 250 were in the inconsistent group and 250 were in the consistent group. In the inconsistent group, the hospital fatality rate was 18%, while in the consistent group it was 10% (p < 0.05). Variability in biomarker levels was an independent predictor of higher hospital mortality, according to multivariate analysis (OR 2.5, 95% CI 1.5–4.2).

Conclusion: Inconsistent CK-MB and troponin levels were associated with higher hospital mortality in ACD patients. Monitoring and stabilizing these biomarkers may be essential for improving patient outcomes and guiding therapeutic interventions in acute care settings.

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Published

02-10-2024

How to Cite

Shah, S. W. U. R. ., Shehzadi, H. ., Shahzadi, N., khalid, Z. ., Naeem, M. ., Qureshi, R. L. ., & Fatima, M. (2024). Impact of Consistent and Inconsistent Creatine Kinase-MB and Troponin Levels on Hospital lethality in Acute Coronary Disorder: Creatine Kinase-MB and Troponin as Mortality Predictors. DEVELOPMENTAL MEDICO-LIFE-SCIENCES, 1(7), 12-19. https://doi.org/10.69750/dmls.01.07.055

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