Clinicodemographic Risk Factors and Maternal Outcomes Associated with Primary Postpartum Hemorrhage. A Prospective Observational Study

Risk Profile of Primary Postpartum Hemorrhage

Authors

  • Tehreem Hayat Department of Obstetrics and Gynaecology, DHA-Certified Medical Practice, Jumeirah Lake Towers (Indigo Icon Tower), Dubai, United Arab Emirates. Author
  • Farah Saleem Senior Consultant Gynecologist, Dr. Faisal Masood Teaching Hospital, Sargodha, Pakistan. Author

DOI:

https://doi.org/10.69750/dmls.03.01.0185

Keywords:

Primary postpartum hemorrhage, uterine atony, mother outcome, anemia, multiparity, obstetric risk factors

Abstract

Background: Primary postpartum hemorrhage (PPH) remains one of the leading causes of maternal morbidity and mortality worldwide, particularly in developing countries. Early identification of clinicodemographic risk factors is essential for prevention and improved maternal outcomes.

Objective: To assess the clinicodemographic risk factors and maternal outcomes associated with primary postpartum hemorrhage in a tertiary care hospital.

Methods: This prospective observational study included 100 women who developed primary PPH within the first 24 hours after delivery. Primary PPH was defined according to World Health Organization criteria. A structured proforma was used to document sociodemographic characteristics, obstetric risk factors, causes of PPH, and maternal outcomes. Data were analyzed using SPSS version 26. Chi-square or Fisher’s exact tests were applied to evaluate associations between risk factors and adverse maternal outcomes, with a p-value <0.05 considered statistically significant.

Results: The mean maternal age was 29.4 years. Major risk factors identified were multiparity (62%), anemia (61%), and rural residence (65%). Cesarean delivery accounted for 44% of cases. Uterine atony was the most common cause of PPH, responsible for 72% of cases. Maternal outcomes included the need for blood transfusion (68%), surgical intervention (19%), ICU admission (15%), and hysterectomy (4%). Maternal mortality was reported in 2% of cases. Anemia, multiparity, cesarean delivery, and prolonged labor showed significant associations with severe maternal outcomes (p ≤ 0.05).

Conclusion: Primary postpartum hemorrhage is strongly associated with modifiable clinicodemographic factors, particularly anemia, multiparity, and inadequate prenatal care. Early risk stratification, correction of maternal hemoglobin levels, and timely obstetric intervention are crucial to reducing severe morbidity and mortality. Strengthening antenatal care and ensuring optimal emergency obstetric preparedness remain key strategies for improving maternal health outcomes.

Downloads

Download data is not yet available.

References

Khedagi AM, Bello NA. Hypertensive disorders of pregnancy. Cardiol Clin. 2021;39:77-90. doi:10.1016/j.ccl.2020.09.005.

Hurrell A, Beardmore-Gray A, Duhig K, Webster L, Chappell LC, Shennan AH. Placental growth factor in suspected preterm pre-eclampsia: evidence and implementation. BJOG. 2020;127:1590-7. doi:10.1111/1471-0528.16425.

Rana S, Burke SD, Karumanchi SA. Angiogenic factor imbalance in preeclampsia and related disorders. Am J Obstet Gynecol. 2022;226:S1019-34. doi:10.1016/j.ajog.2020.10.022.

Parchem JG, Brock CO, Chen HY, Kalluri R, Barton JR, Sibai BM. Placental growth factor and adverse neonatal and maternal outcomes. Obstet Gynecol. 2020;135:665-73. doi:10.1097/AOG.0000000000003694.

Duhig KE, Myers JE, Gale C, et al. Placental growth factor measurement in suspected preeclampsia: PARROT trial analysis. Pregnancy Hypertens. 2021;23:41-7. doi:10.1016/j.preghy.2020.10.005.

Gladstone RA, Ahmed S, Huszti E, et al. Midpregnancy placental growth factor screening and early preterm birth. JAMA Netw Open. 2024;7:e2444454. doi:10.1001/jamanetworkopen.2024.44454.

McLaughlin K, Snelgrove JW, Audette MC, et al. Placental growth factor testing in clinical practice. Hypertension. 2021;77:2057-65. doi:10.1161/HYPERTENSIONAHA.121.17047.

Leaños-Miranda A, Nolasco-Leaños AG, Carrillo-Juárez IR, et al. Usefulness of the sFlt-1/PlGF ratio in confirming or excluding preeclampsia. Hypertension. 2020;76:892-900. doi:10.1161/HYPERTENSIONAHA.120.15552.

Chen J, Zhao M, Zhou R, et al. Medical expense burden in older adults. Front Public Health. 2023;11:1165381. doi:10.3389/fpubh.2023.1165381.

Fu X, Ren X, Chen Q. National medical reform and healthcare burden in Chinese provinces. Front Public Health. 2024;12:1444840. doi:10.3389/fpubh.2024.1444840.

Tian T, Lu J, Zhao W, et al. Systemic inflammation markers and pulmonary nodules/lung cancer identification. Cancer Med. 2022;11:2482-91. doi:10.1002/cam4.4606.

Arredondo Montero J, Delgado-Miguel C, Pérez Riveros BP, et al. Systemic immune-inflammation index for diagnosing acute appendicitis: systematic review. J Surg Res. 2025;309:88-102. doi:10.1016/j.jss.2025.03.002.

Altuğ E, Kılavuz H, Çakir A, et al. Diagnostic value of SII in acute and complicated appendicitis during pregnancy. Langenbecks Arch Surg. 2024;409(1):222. doi:10.1007/s00423-024-03420-x.

Cakcak İE, Türkyılmaz Z, Demirel T. Relationship between SIRI/SII values and appendicitis complications during COVID-19. Ulus Travma Acil Cerrahi Derg. 2022;28:751-5. doi:10.14744/tjtes.2021.94580.

Duyan M, Vural N. Diagnostic value of novel biomarkers in adult acute appendicitis. Cureus. 2022;14:e32307. doi:10.7759/cureus.32307.

Berhuni MS, Yönder H, Elkan H, et al. Systemic immune-inflammation index to identify complicated acute appendicitis. Cureus. 2024;16:e73046. doi:10.7759/cureus.73046.

Afridi MA, Khan I, Khalid MM, Ullah N. Combined inflammatory markers and ultrasound for diagnosing acute appendicitis. Ultrasound. 2023;31:266-72. doi:10.1177/1742271X231178112.

Saridas A, Vural N, Duyan M, et al. New inflammatory markers predicting complicated appendicitis. Open Med (Wars). 2024;19:20241002. doi:10.1515/med-2024-1002.

Zhang X, Xu Q, Yang L, et al. Prediction models for hypertensive disorders of pregnancy subtypes. Front Surg. 2022;9:1005974. doi:10.3389/fsurg.2022.1005974.

Ontario Health. PLGF-based biomarker testing for suspected preeclampsia: health technology assessment. Ont Health Technol Assess Ser. 2023;23:1-146.

Downloads

Crossmark - Check for Updates PlumX Metrics

Published

31-01-2026

How to Cite

Hayat, . T., & Saleem, F. (2026). Clinicodemographic Risk Factors and Maternal Outcomes Associated with Primary Postpartum Hemorrhage. A Prospective Observational Study: Risk Profile of Primary Postpartum Hemorrhage. DEVELOPMENTAL MEDICO-LIFE-SCIENCES, 3(1), 20-24. https://doi.org/10.69750/dmls.03.01.0185

Share