Prevalence of Cardiovascular Risk Factors in Patients with Type 2 Diabetes Mellitus Attending Tertiary Care Hospitals
Cardiovascular Risk Profile in Type 2 Diabetes Mellitus
DOI:
https://doi.org/10.69750/dmls.02.010.0159Keywords:
Type 2 Diabetes Mellitus, Cardiovascular Risk Factors, Hypertension, Dyslipidemia, Obesity, PakistanAbstract
Background: Type 2 Diabetes Mellitus (T2DM) is a persistent metabolic illness that significantly enhances the chances of cardiovascular morbidity and death. Hypertension, dyslipidemia, obesity, smoking, and inadequate glycemic control are cardiovascular risk factors that are common in patients with diabetes, which increase complications of the disease. Determinants of their prevalence would be essential in formulating preventive and management programs, particularly in tertiary care environments where complex and uncontrolled cases would be commonly found.
Objective: To establish the prevalence and distribution of the most common risk factors in patients with Type 2 Diabetes Mellitus when they visit Shaikh Zayed Medical Complex.
Methods: The study was a descriptive cross-sectional study carried out between June 2024 and April 2025 in the Department of Endocrinology, Shaikh Zayed Medical Complex, Lahore. The number of patients enrolled was 90 adult T2DM patients aged 35 to 70 years, with a convenience sampling. Structured questionnaires and hospital records were used in the collection of demographics, clinical, and biochemical data. Hypertension, dyslipidemia, obesity, smoking, and poor glycemic control criteria were identified by the standard ADA 2024. The data were analyzed in SPSS version 26, and the results were in mean, SD, and percentages.
Results: The average age of the participants stood at 54.73/8.56 years old, and the proportion of males and females was 57.8/42.2. The hypertension and dyslipidemia were 72.2 and 71.1, respectively; obesity was 44.4; poor glycemic control (HbA1c >7) was 75.6; and smoking was 27.8, respectively. Clustering of risk factors was frequent- 71.1% of the participants had two or more cardiovascular risk factors, and 21.1% had three or more risk factors at the same time. Females were much more likely to be obese (p = 0.04) and males to smoke (p < 0.001).
Conclusion: T2DM patients had a high prevalence of modifiable cardiovascular risk factors, with the predominant ones being hypertension, dyslipidemia, and lack of glycemic control. There is a real need to combine screening, risk stratification, and lifestyle modification programs in managing diabetes to avoid the occurrence of cardiovascular complications in the future due to the co-existence of multiple risk factors.
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References
Basit A, Tanveer S, Fawwad A, Naeem N; NDSP Members. Prevalence and contributing risk factors for hypertension in urban and rural areas of Pakistan; a study from the Second National Diabetes Survey of Pakistan (NDSP) 2016–2017. Clin Exp Hypertens. 2020;42(3):218-224. doi:10.1080/10641963.2019.1619753
Basit A, Fawwad A, Qureshi H, Shera AS; NDSP Members. Prevalence of diabetes, pre-diabetes and associated risk factors: second National Diabetes Survey of Pakistan (NDSP), 2016–2017. BMJ Open. 2018;8(6):e020961. doi:10.1136/bmjopen-2017-020961
Aamir AH, Ul-Haq Z, Mahar SA, et al. Diabetes Prevalence Survey of Pakistan (DPS-PAK): prevalence of type 2 diabetes and prediabetes using HbA1c. BMJ Open. 2019;9(2):e025300. doi:10.1136/bmjopen-2018-025300
NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1,108 population-representative studies. Lancet. 2024;404(10423):223-237. doi:10.1016/S0140-6736(24)02317-1
GBD 2021 Diabetes Collaborators. Global, regional, and national burden of diabetes, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2023;402(10397):203-234. doi:10.1016/S0140-6736(23)01301-6
American Diabetes Association Professional Practice Committee. 10. Cardiovascular disease and risk management: Standards of Care in Diabetes—2024. Diabetes Care. 2024;47(Suppl 1):S179-S218. doi:10.2337/dc24-S010
American Diabetes Association Professional Practice Committee. Summary of Revisions: Standards of Care in Diabetes—2025. Diabetes Care. 2025;48(Suppl 1):S6-S13. doi:10.2337/dc25-SREV
Khan MS, Ali MA, Almas A. Challenges of managing hypertension in Pakistan. Clin Hypertens. 2023;29:34. doi:10.1186/s40885-023-00245-6
Hasan SU, Siddiqui MR. Epidemiology of diabetes mellitus in Pakistan: a systematic review and meta-analysis. BMJ Open. 2024;14(5):e079513. doi:10.1136/bmjopen-2023-079513
Taimur H, Khan A, Kiran R, et al. A scoping review of type 2 diabetes mellitus in Pakistan: prevalence, complications, and outcomes. Front Endocrinol (Lausanne). 2024;15:1441591. doi:10.3389/fendo.2024.1441591
Ide S, Maezawa Y, Yokote K. Updates on dyslipidemia in patients with diabetes. J Diabetes Investig. 2023;14(9):1041-1044. doi:10.1111/jdi.14042
Strikić D, Bilić-Ćurčić I, Đogaš Z, Radić R. Diabetic dyslipidemia: pathophysiology, clinical significance and therapeutic approaches. Diabetology. 2023;4(4):538-552. doi:10.3390/diabetology4040048
Yang Y, Wei N, Inoue K, et al. Smoking, smoking cessation, and risk of cardiovascular disease in patients with type 2 diabetes: a systematic review and meta-analysis. Cardiovasc Diabetol. 2022;21:14. doi:10.1186/s12933-022-01447-2
Cosentino F, Grant PJ, Aboyans V, et al. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J. 2020;41(2):255-323. doi:10.1093/eurheartj/ehz486
Arnett DK, Blumenthal RS, Albert MA, et al. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease. Circulation. 2019;140(11):e596-e646. doi:10.1161/CIR.0000000000000678
Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol. J Am Coll Cardiol. 2019;73(24):3168-3209. doi:10.1016/j.jacc.2018.11.003
Hasan SU, Siddiqui MR. Prevalence and associated factors of dyslipidemia among type 2 diabetes patients in Pakistan: a systematic review and meta-analysis. Pak J Med Sci. 2025;41(2):—. doi:10.12669/pjms.41.2.10264
Amin F, Ali M, Nawaz W, et al. Diabetes and its associated factors: a retrospective cohort study at a tertiary care hospital in Pakistan. Pak J Med Sci. 2024;40(2 Suppl): S10-S14. doi:10.12669/pjms.40.2(ICON).8948
Valensi P, Avignon A, Sultan A, et al. Performance of the 2019 ESC/EASD guideline strategy for silent myocardial ischemia screening in very high-risk type 2 diabetes. Cardiovasc Diabetol. 2023;22:159. doi:10.1186/s12933-023-01760-4
Taheri A, Amini M, Rezaianzadeh A, et al. Hypertension among persons with type 2 diabetes and its associated factors: results from the Fasa cohort. Sci Rep. 2024;14:14187. doi:10.1038/s41598-024-69062-7















