Persistence and Efficacy of Maternal COVID-19 Vaccine-Induced Antibodies in Human Milk: A Comprehensive Meta-Analysis

Analyzing the Durability and Impact of COVID-19 Vaccine Antibodies in Breast Milk

Authors

  • Neha Fatima Pharmacy Department, Lahore Medical & Dental College (LMDC), Lahore, Pakistan. Author
  • Syeda Nawal Fatima BDS, Lahore Medical & Dental College (LMDC), Lahore, Pakistan. Author
  • Nisha noor Pharmacy Department, Lahore Medical & Dental College (LMDC), Lahore, Pakistan Author
  • Marium Khan BDS, Lahore Medical & Dental College (LMDC), Lahore, Pakistan. Author
  • Khadija Yahya BDS, Lahore Medical & Dental College (LMDC), Lahore, Pakistan. Author
  • Mustafa Rizwan Pharmacy Department, Lahore Medical & Dental College (LMDC), Lahore, Pakistan. Author
  • Mamoona Shuja MBBS, Al Aleem Medical College, Lahore, Pakistan Author
  • Muhammad Nasir Shahbaz Institute of Molecular Biology and Biotechnology (IMBB), CRIMM, The University of Lahore, Lahore Pakistan Author

DOI:

https://doi.org/10.69750/dmls.01.02.022

Keywords:

COVID-19; SARS-CoV-2; antibodies; human milk; maternal vaccination; passive immunity; breastfeeding; IgA; IgG; meta-analysis.

Abstract

Abstract

Background: The ongoing global health challenge posed by the COVID-19 pandemic has necessitated a thorough examination of vaccine efficacy, particularly the transfer of vaccine-induced immunity to infants via human milk. This meta-analysis aims to explore the persistence and efficacy of COVID-19 vaccine-induced antibodies in human milk, offering insights into passive immunity transfer to breastfeeding infants.

Methods: We conducted a systematic review and meta-analysis of peer-reviewed studies published from January 2021 to December 2023, extracted from databases such as PubMed, Scopus, and Web of Science. Our focus was on studies measuring SARS-CoV-2-specific antibodies (IgA and IgG) in human milk following maternal COVID-19 vaccination.

Results: Fifteen studies involving 1,200 lactating mothers who received mRNA COVID-19 vaccines were included. The analysis highlighted a consistent presence of SARS-CoV-2-specific IgA and IgG antibodies in human milk, persisting for up to six months post-vaccination.

Conclusion: The results highlight the noteworthy transmission of COVID-19 antibodies via human milk, suggesting an extended duration of possible protection for neonates against SARS-CoV-2 infection. This argues in favor of immunizing nursing mothers as a preemptive public health strategy to provide their children passive immunity.

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Published

28-05-2024

How to Cite

Fatima , N. ., Fatima, S. N., Noor, N. ., Khan, M. ., Yahya, K., Rizwan, M. ., Shuja, M., & Shahbaz, M. N. (2024). Persistence and Efficacy of Maternal COVID-19 Vaccine-Induced Antibodies in Human Milk: A Comprehensive Meta-Analysis: Analyzing the Durability and Impact of COVID-19 Vaccine Antibodies in Breast Milk. DEVELOPMENTAL MEDICO-LIFE-SCIENCES, 1(2), 8-19. https://doi.org/10.69750/dmls.01.02.022

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